Inguinal hernias are quite common in men. They occur in the groin area and are well-known to be associated with improper lifting technique. A hernia of this type is when a piece of small intestines moves through a weakness in the muscular wall of the body. Most do not cause any symptoms like pain or discomfort, and most others cause only mild symptoms.
If a hernia is causing severe pain, or has visibly moved into the scrotum or canal between the abdomen and scrotum (known as the inguinal canal), then surgery may be essential. If sudden, sharp, unrelenting pain occurs in the groin area then emergency care should be sought, as the hernia is said to have incarcerated or gotten blocked. This can be life threatening in very rare cases and should NOT be ignored in hopes it will “go away on its own.”
Several classes of common medications lower serum total prostate-specific antigen (tPSA) levels according to a 2010 publication by Chang, et al. Statins, non-steroidal anti-inflammatory drugs (NSAIDs), and thiazide diuretics, among the most commonly used drugs in the world, all significantly lowered tPSA in this analysis of 1,864 American men over the age of 40 years. Use of a thiazide and a statin together for 5 years led to a 36% reduction in tPSA levels. Calcium channel blockers actually eliminated this effect of statins on tPSA. It is unknown how these medications cause this effect.
It is possible these drugs have been interfering with the tPSA test's ability to accurately detect prostate cancer. By artificially suppressing tPSA levels, these drugs could hide a more serious problem. It is also possible they may actually be treating prostate cancer in some way. More research is needed on this crucial matter.
Chang SL, Harshman LC, Presti JC Jr. Impact of common medications on serum total prostate-specific antigen levels: Analysis of the National Health and Nutrition Examination Survey. J Clin Oncol 2010;28(25):3951-7.
Two large randomized trials published in the New England Journal of Medicine dealt two further devastating blows to the idea of using the total prostate-specific antigen (tPSA) blood test to screen for cancer. I say tPSA to differentiate it from the less-commonly tested free PSA (fPSA) or complexed PSA (cPSA).