Several classes of common medications lower serum total prostate-specific antigen (tPSA) levels according to a 2010 publication by Chang, et al. Statins, non-steroidal anti-inflammatory drugs (NSAIDs), and thiazide diuretics, among the most commonly used drugs in the world, all significantly lowered tPSA in this analysis of 1,864 American men over the age of 40 years. Use of a thiazide and a statin together for 5 years led to a 36% reduction in tPSA levels. Calcium channel blockers actually eliminated this effect of statins on tPSA. It is unknown how these medications cause this effect.
It is possible these drugs have been interfering with the tPSA test's ability to accurately detect prostate cancer. By artificially suppressing tPSA levels, these drugs could hide a more serious problem. It is also possible they may actually be treating prostate cancer in some way. More research is needed on this crucial matter.
Chang SL, Harshman LC, Presti JC Jr. Impact of common medications on serum total prostate-specific antigen levels: Analysis of the National Health and Nutrition Examination Survey. J Clin Oncol 2010;28(25):3951-7.